Understand (and aim for) wealth, as opposed to money or status, and radically accept human nature.
Then, learn to create unique value for society by combining foundational knowledge (such as that learned through exposure to markets and physics) with specialised, cutting-edge knowledge (learned through following curiosity).
Abstract out the durable compounding mechanisms at play, and plow as many resources as you can towards them.
Commit to the best plan you have, and allow each step forward to illuminate the next.
In the process, provide more value than you consume, and always keep your promises (thus building a solid reputation).
Ignore the "lucky breaks" of others.
Extend your time horizon as far as you can into the future, and hedge your bets to ensure you aren't taken out of the game.
And if you do all this, you’ll never have to worry about being replaced (for as long as replacement is a worthwhile worry).
There’s only one question left: where could we go wrong?